Versatile solid-phase syntheses of trisubstituted pyrazole carboxylic acids
, trisubstituted pyridines and disubstituted pyridones are presented. Pyraz
oles are prepared by reaction of polymer bound arylidene- or alkylidene-bet
a-oxo esters with phenylhydrazines. Pyridines result from the Krohnke react
ion of immobilised enones with 1-(2-oxo-2-arylethyl)pyridinium salts and am
monium acetate. Pyridones are obtained from polymer bound enones, 1-(methox
y-carbonylmethyl)pyridinium bromide and ammonium acetate.