The effect of denervation on leukocyte function in soft tissue infection

Citation
Ps. Hui et al., The effect of denervation on leukocyte function in soft tissue infection, SURGERY, 126(5), 1999, pp. 933-938
Citations number
14
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Surgery,"Medical Research Diagnosis & Treatment
Journal title
SURGERY
ISSN journal
0039-6060 → ACNP
Volume
126
Issue
5
Year of publication
1999
Pages
933 - 938
Database
ISI
SICI code
0039-6060(199911)126:5<933:TEODOL>2.0.ZU;2-L
Abstract
Background. The present study was undertaken to investigate the effect of d enervation on leukocyte function in soft-tissue infection in an isolated in vivo ovine flap model. Methods. Fifteen adult ewes were divided into three groups. An island pedic le flap was raised on the right buttock, In group I (no denervation), the c utaneous nerve remained intact, whereas in group II (acute denervation) the nerve was divided acutely. In group III (prolonged denervation) the nerve was divided 7 days before flap elevation. All flaps received intradermal in oculation of 10(7) Staphylococcus aureus, and the animals were observed for 96 hours. Results, In both groups II and III, the leukocyte chemiluminescence and che motaxis were significantly decreased when compared with group I Furthermore , there was profound impairment of leukocyte functions in group III compare d with group II. Group III also had significantly higher bacterial counts, larger septic foci, lower viable leukocyte ratios, and decreased bacterial killing compared with group I. Conclusions, Denervation, particularly over a period of time, results in in creased bacterial growth of soft-tissue septic foci. This appears to be due to decreased leukocyte function resulting in diminished bacterial killing.