No detected mutations in the genes for the amyloid precursor protein and presenilins 1 and 2 in a Swiss early-onset Alzheimer's disease family with adominant mode of inheritance

Citation
A. Savioz et al., No detected mutations in the genes for the amyloid precursor protein and presenilins 1 and 2 in a Swiss early-onset Alzheimer's disease family with adominant mode of inheritance, DEMENT G C, 10(6), 1999, pp. 431-436
Citations number
25
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurology,"Neurosciences & Behavoir
Journal title
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
ISSN journal
1420-8008 → ACNP
Volume
10
Issue
6
Year of publication
1999
Pages
431 - 436
Database
ISI
SICI code
1420-8008(199911/12)10:6<431:NDMITG>2.0.ZU;2-M
Abstract
Mutations have been found in more than a hundred early-onset families with Alzheimer's disease (AD) in the genes for the amyloid precursor protein, pr esenilin 1 and presenilin 2. The object of our investigation was to identif y if these mutations or novel ones were operating in a Swiss early-onset AD family (mean age of onset: 53.3 years) with 7 members available, all neuro pathologically confirmed. No known or new mutations were detected. Thus, ou r data support the existence of a yet unknown mutation, or other genes, con tributing to familiar early onset AD. Copyright (C) 1999 S. Karger AG,Basel .