Comparison of different routes of administration of nadroparin in hemodialysis

Citation
Jl. Vanuytsel et al., Comparison of different routes of administration of nadroparin in hemodialysis, CLIN NEPHR, 52(5), 1999, pp. 322-325
Citations number
7
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Urology & Nephrology","da verificare
Journal title
CLINICAL NEPHROLOGY
ISSN journal
0301-0430 → ACNP
Volume
52
Issue
5
Year of publication
1999
Pages
322 - 325
Database
ISI
SICI code
0301-0430(199911)52:5<322:CODROA>2.0.ZU;2-3
Abstract
Aim: In an open, crossover, randomized study in hemodialysis patients, we i nvestigated possible differences of the effect of the low molecular weight heparin (LMWH) nadroparin/fraxiparine in relation to the route of administr ation. Patients and methods: The effect of nadroparin, administered by the venous line or by the arterial line after priming of the extracorporeal cir cuit with a part of the total dose administered, was compared with administ ration of the same dose by the arterial line as recommended by the manufact urer. Twelve stable, chronic hemodialysis patients were studied during 3 di alysis sessions for each treatment option. Concomitant medication was kept constant. Results: Results obtained after administration of nadroparin by t he venous line were comparable to those obtained after administration by th e arterial line. When a part of the dose was added to the priming solution, the anti-Xa activity, measured after 2 hours of dialysis, was somewhat low er (p = 0.09). There was also a tendency towards longer manual compression time in this group. There was no difference in hemoglobine, serum urea and creatinine before the study and at the end of each treatment option. Conclu sion: We therefore conclude that the safety and efficacy of administration of LMWH by the arterial and by the venous route are identical. There is no need for addition of a small dose of LMWH to the priming fluid.