Clinicopathological study of myeloperoxidase anti-neutrophil cytoplasmic antibody-associated glomerulonephritis

Citation
N. Yorioka et al., Clinicopathological study of myeloperoxidase anti-neutrophil cytoplasmic antibody-associated glomerulonephritis, CLIN NEPHR, 52(5), 1999, pp. 293-296
Citations number
12
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Urology & Nephrology","da verificare
Journal title
CLINICAL NEPHROLOGY
ISSN journal
0301-0430 → ACNP
Volume
52
Issue
5
Year of publication
1999
Pages
293 - 296
Database
ISI
SICI code
0301-0430(199911)52:5<293:CSOMAC>2.0.ZU;2-J
Abstract
Aims: To investigate the potential prognostic factors for myeloperoxidase a nti-neutrophil cytoplasmic antibody- (MPO-ANCA) associated glomerulonephrit is. Materials: The clinical and pathological findings were reviewed in 17 p atients with this type of glomerulonephritis. Methods: The relationship bet ween the outcome and various clinical and pathological factors were assesse d. The relationship between the blood MPO-ANCA level and cellular crescent formation was also investigated. Results: Patients who died had a significa ntly lower serum albumin and creatinine clearance than those who survived, but there were no differences of age, blood MPO-ANCA, urinary protein, and serum creatinine levels or cellular crescent formation between the two grou ps. There Was a close relationship between blood MPO-ANCA levels and cellul ar crescent formation. Conclusions: Hypoalbuminemia and renal dysfunction m ay be indicators of a poor prognosis in MPO-ANCA-associated glomerulonephri tis. Patients with high blood levels of this antibody and increased cellula r crescent formation appear to have active disease, but these factors are n ot statistically associated with a fatal outcome. Therefore, aggressive tre atment may be indicated in patients with active disease initially.