Energy deficits suppress both systemic and gut immunity during infection

Citation
Kg. Koski et al., Energy deficits suppress both systemic and gut immunity during infection, BIOC BIOP R, 264(3), 1999, pp. 796-801
Citations number
24
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Biochemistry & Biophysics
Journal title
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
ISSN journal
0006-291X → ACNP
Volume
264
Issue
3
Year of publication
1999
Pages
796 - 801
Database
ISI
SICI code
0006-291X(19991102)264:3<796:EDSBSA>2.0.ZU;2-9
Abstract
Protein-energy malnutrition and gastrointestinal nematode infections widely coexist in developing countries. Evidence is provided demonstrating the pr ofound impact of dietary energy deficiency on immune function. Energy-restr icted (ER) mice infected with a gastrointestinal nematode showed impaired l ymphocyte proliferation and reduced production of Th2 cytokines and lower l evels of IgE, parasite-specific IgG1, and eosinophils, which led to higher worn burdens and fecundity. We conclude that mild ER, without concurrent pr otein malnutrition, can modulate protective immunity from (a) activation ea rly during a primary infection to (b) the expression of acquired immunity d uring reinfection in both systemic and gut-associated lymphoid tissues. (C) 1999 Academic Press.