Role of angiotensin and oxidative stress in essential hypertension

Citation
Jc. Romero et Jf. Reckelhoff, Role of angiotensin and oxidative stress in essential hypertension, HYPERTENSIO, 34(4), 1999, pp. 943-949
Citations number
73
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Journal title
HYPERTENSION
ISSN journal
0194-911X → ACNP
Volume
34
Issue
4
Year of publication
1999
Part
2
Supplement
S
Pages
943 - 949
Database
ISI
SICI code
0194-911X(199910)34:4<943:ROAAOS>2.0.ZU;2-V
Abstract
In this review, we examine the possibility that small increments in angiote nsin II are responsible for an increase in blood pressure and maintenance o f hypertension through the stimulation of oxidative stress. A low dose of a ngiotensin II (2 to 10 ng . kg(-1) . min(-1), which does not elicit an imme diate presser response), when given for 7 to 30 days by continuous intraven ous infusion, can increase mean arterial pressure by 30 to 40 mm Hg. This s low presser response to angiotensin is accompanied by the stimulation of ox idative stress, as measured by a significant increase in levels of 8-iso-pr ostaglandin F-2 alpha (F-2-isoprostane). Superoxide radicals and nitric oxi de can combine chemically to form peroxynitrite, which can then oxidize ara chidonic acid to form F-2-isoprostanes. F-2-isoprostanes exert potent vasoc onstrictor and antinatriuretic effects. Furthermore, angiotensin II can sti mulate endothelin production, which also has been shown to stimulate oxidat ive stress. In this way, a reduction in the concentration of nitric oxide ( which is quenched by superoxide) along with the formation of F-2-isoprostan es and endothelin could potentiate the vasoconstrictor effects of angiotens in II. We hypothesize that these mechanisms, which underlie the development of the slow presser response to angiotensin II, also participate in the pr oduction of hypertension when circulating angiotensin II levels appear norm al, as occurs in many cases of essential and renovascular hypertension.