Treadmill exercise-induced stress causes a rise of blood histamine in normotensive but not in primary hypertensive humans

Citation
Ha. Campos et al., Treadmill exercise-induced stress causes a rise of blood histamine in normotensive but not in primary hypertensive humans, EUR J PHARM, 383(1), 1999, pp. 69-73
Citations number
21
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Pharmacology & Toxicology
Journal title
EUROPEAN JOURNAL OF PHARMACOLOGY
ISSN journal
0014-2999 → ACNP
Volume
383
Issue
1
Year of publication
1999
Pages
69 - 73
Database
ISI
SICI code
0014-2999(19991021)383:1<69:TESCAR>2.0.ZU;2-F
Abstract
We have previously shown an interaction between noradrenergic and histamine -containing neurons in the rat vas deferens. As a generalized phenomenon, t his interaction is involved in a novel peripheral reflex that, in an inhibi tory way, modulates sympathetic activity and arterial pressure. Consistent with this, an activation of postganglionic sympathetic neurons causes a ris e in rat blood histamine. In the present study, we showed that enhanced sym pathetic activity due to treadmill exercise in normotensive humans, is acco mpanied by a rise in blood histamine, suggesting the presence of a similar neuronal interaction in humans. In contrast, the rise in blood histamine do es not occur in primary hypertensive humans during the same degree of physi cal exercise, suggesting that this interaction is faulty in such hypertensi ves and could be involved in the pathophysiology of the disease. (C) 1999 E lsevier Science B.V. All rights reserved.