Spontaneous accumulation of eosinophils and macrophages throughout the stroma of the epididymis and vas deferens in alymphoplasia (aly) mutant mice: I. A histological study

Citation
M. Itoh et al., Spontaneous accumulation of eosinophils and macrophages throughout the stroma of the epididymis and vas deferens in alymphoplasia (aly) mutant mice: I. A histological study, AM J REPROD, 42(4), 1999, pp. 246-253
Citations number
13
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Immunology
Journal title
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
ISSN journal
1046-7408 → ACNP
Volume
42
Issue
4
Year of publication
1999
Pages
246 - 253
Database
ISI
SICI code
1046-7408(199910)42:4<246:SAOEAM>2.0.ZU;2-7
Abstract
PROBLEM: The alymphoplasia (aly) mutation of mice causes the systemic absen ce of lymph nodes and Peyer's patches. Histopathological analysis has revea led that lymphocytes accumulate in some organs such as the salivary glands, lungs, kidneys, liver, and pancreas of homozygotes (aly/aly) but not heter ozygotes (aly/+). However, the presence of lymphocytic accumulation in male reproductive tissues of aly/aly mice has not been reported. METHOD OF STUDY: The male reproductive organs of homozygous aly/aly, hetero zygous aly/+, and other immunodeficient mice bred in a specific pathogen-fr ee state were histologically investigated. RESULTS: Testes, ductuli efferentes, prostates, coagulating glands, and sem inal vesicles of homozygous aly/aly mice were free from any pathological ac cumulation of leukocytes. However, their epididymides and vasa deferentia e xhibited massive infiltration by leukocytes, which were composed of eosinop hils and macrophages. In all homozygotes examined, both eosinophils and mac rophages were extensively observed throughout the stroma of the epididymis and vas deferens, but never within the epithelium or lumen of the ducts, wi th no parenchymal tissue damage. The accumulation of eosinophils was never found in nonreproductive organs. In aly/+ heterozygous mice and other immun odeficient mice, no pathological accumulation of leukocytes were noted. CONCLUSIONS: The accumulation of eosinophils and macrophages is specific to the epididymides and vasa deferentia of immunodeficient aly/aly homozygote s, although the pathogenesis remains unknown.