A placenta-derived suppressor factor with a T-cell bias

Citation
R. Raghupathy et al., A placenta-derived suppressor factor with a T-cell bias, AM J REPROD, 42(4), 1999, pp. 205-218
Citations number
41
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Immunology
Journal title
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
ISSN journal
1046-7408 → ACNP
Volume
42
Issue
4
Year of publication
1999
Pages
205 - 218
Database
ISI
SICI code
1046-7408(199910)42:4<205:APSFWA>2.0.ZU;2-0
Abstract
PROBLEM: Functional and mechanistic aspects of immunosuppression by murine placental supernatants (MPS) were investigated. METHOD OF STUDY: MPS and a low molecular weight fraction of the supernatant (MPSf) were tested for suppressive action on T-cell reactivity in vitro an d in vivo, on B-cell responses and on T-cell activation events. RESULTS: MPS and MPSf suppress mitogen-induced proliferation and mixed lymp hocyte reactions of human and murine lymphocytes, antigen-induced prolifera tion of T cells in vitro and in vivo, proliferation of CD8(+) lymphocytes, proliferation induced by cross-linking of surface CD3 and the in vivo respo nse of mice to allogeneic stimuli. MPSf affects cell cycling of activated T cells and blocks interleukin (IL)-2 production. MPSf does not affect antib ody production or the induction of MHC class II expression on B cells. CONCLUSIONS: MPSf is a potent inhibitor of T-cell responses in vitro and in vivo, with no demonstrable effect on B-cell function.