M. Makhseed et al., Mitogen-induced cytokine responses of maternal peripheral blood lymphocytes indicate a differential Th-type bias in normal pregnancy and pregnancy failure, AM J REPROD, 42(5), 1999, pp. 273-281
PROBLEM: Profiles of Th1- and Th2-type cytokines were studied in women with
a history of successful pregnancy and in women with a history of unexplain
ed recurrent spontaneous abortions (RSA) with the objective of elucidating
Th1- and Th2-type bias in normal pregnancy and pregnancy failure.
METHOD OF STUDY: Peripheral blood mononuclear cells (PBMCs) from 54 women w
ith a history of normal pregnancy and 23 women with a history of unexplaine
d RSA, obtained at delivery or on the day of abortion, respectively, were s
timulated with phytohemagglutinin (PHA), followed by the estimation of four
Th2 cytokines and four Th1 cytokines.
RESULTS: Significantly greater levels of Th2 cytokines were produced by the
normal group than by the RSA group. On the other hand, significantly highe
r levels of Th1 cytokines were produced by the RSA group than by the normal
CONCLUSIONS: These data support the concept that unexplained recurrent spon
taneous abortion is associated with an increase in Th1-type reactivity, whi
le Th2 dominance is a feature of successful pregnancy.