Increased levels of nitrite/nitrate in the cerebrospinal fluid of patientswith subarachnoid hemorrhage

Citation
M. Suzuki et al., Increased levels of nitrite/nitrate in the cerebrospinal fluid of patientswith subarachnoid hemorrhage, NEUROSURG R, 22(2-3), 1999, pp. 96-98
Citations number
16
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurology
Journal title
NEUROSURGICAL REVIEW
ISSN journal
0344-5607 → ACNP
Volume
22
Issue
2-3
Year of publication
1999
Pages
96 - 98
Database
ISI
SICI code
0344-5607(199910)22:2-3<96:ILONIT>2.0.ZU;2-M
Abstract
The role of nitric oxide (NO) in the mechanism of delayed cerebral vasospas m (VS) after subarachnoid hemorrhage (SAH) was investigated by analyzing th e stable metabolites of NO, nitrite and nitrate, by the Griess method in th e cerebrospinal fluid (CSF) and venous blood of 29 patients with SAH, the C SF of 22 control patients, and venous blood from eight normal subjects. VS was defined as diffuse and severe angiographical vasospasm detected by angi ography performed around days 7-9 after the onset. Six of the 29 patients h ad VS. The nitrite/nitrate levels in the blood of patients with SAH were al most within the range of those in normal subjects, but the levels in the CS F of patients with SAH were significantly higher than those of the control group. Patients with VS after SAH had significantly lower levels in the CSF than patients without VS on days 7-9, when VS is most likely to occur. The se observations suggest that NO production in the CSF environment occurs fo llowing SAH, but possibly may not provoke VS.