Effect of ileojejunal transposition on gastrointestinal motility, gastric emptying, and small intestinal transit in dogs

Citation
N. Ohtani et al., Effect of ileojejunal transposition on gastrointestinal motility, gastric emptying, and small intestinal transit in dogs, J GASTRO S, 3(5), 1999, pp. 516-523
Citations number
20
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Surgery
Journal title
JOURNAL OF GASTROINTESTINAL SURGERY
ISSN journal
1091-255X → ACNP
Volume
3
Issue
5
Year of publication
1999
Pages
516 - 523
Database
ISI
SICI code
1091-255X(199909/10)3:5<516:EOITOG>2.0.ZU;2-O
Abstract
There is speculation that enteroglucagon and peptide YY are responsible for mediating the "ileal brake" known as a suppressive reaction of upper grast rointestinal motility and transit that is induced by the infusion of nutrie nts into the ileum. We studied changes in motility and transit in dogs with ileojejunal transposition in which the distal ileum is exposed to undigest ed nutrients. Nine adult mongrel dogs were equipped with strain gauge force transducers placed on the gastric body, antrum, duodenum, and proximal jej unum. Measurements of gastrointestinal motility, gastric emptying, and plas ma levels of total glucagon-like immunoreactivity, immunoreactive glucagon, and peptide YY were obtained both before and after either ileojejunal tran sposition (5 dogs) or sham operation (4 clogs). Postprandial contractions i n the gastric antrum and gastric emptying were significantly inhibited afte r ileojejunal transposition. The inhibitory effect of ileojejunal transposi tion on antral motor activity was found to correlate with the rise in plasm a total glucagon-like immunoreactivity and peptide YY concentrations. Howev er, plasma glucagon levels were unaffected by ileojejunal transposition. Th ese results sub best that hypersecretion of enteroglucagon and peptide YY i nduced by ileojejunal transposition inhibits postprandial gastric motor fun ction.