Salt water promotes hypertension in Dahl-S rats

Citation
N. Miura et al., Salt water promotes hypertension in Dahl-S rats, EXP ANIM, 48(4), 1999, pp. 289-292
Citations number
11
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Animal Sciences
Journal title
EXPERIMENTAL ANIMALS
ISSN journal
1341-1357 → ACNP
Volume
48
Issue
4
Year of publication
1999
Pages
289 - 292
Database
ISI
SICI code
1341-1357(199910)48:4<289:SWPHID>2.0.ZU;2-9
Abstract
Hypertension was induced in Dahl-salt-sensitive (Dahl-S) rats by administer ing salt in drinking water. Control rats receiving tap water did not show a significant change in blood pressure or abnormalities in the kidney. Rats receiving 0.5% NaCl solution developed moderate hypertension and renal lesi ons. Rats receiving 1.0% NaCl solution showed prominent and increasing hype rtension and severe renal damage. This method of salt administration should be simpler than administration in the diet as a means of promoting renal h ypertension. The lower concentration salt water caused chronic mild hyperte nsion in Dahl-S rats, and may serve as a useful model for progressive hyper tension.