Antitumor agents 200. Cytotoxicity of naturally occurring resveratrol oligomers and their acetate derivatives

Citation
M. Ohyama et al., Antitumor agents 200. Cytotoxicity of naturally occurring resveratrol oligomers and their acetate derivatives, BIOORG MED, 9(20), 1999, pp. 3057-3060
Citations number
14
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960-894X → ACNP
Volume
9
Issue
20
Year of publication
1999
Pages
3057 - 3060
Database
ISI
SICI code
0960-894X(19991018)9:20<3057:AA2CON>2.0.ZU;2-W
Abstract
Eleven resveratrol oligomers and six acetylated derivatives were evaluated for in vitro cytotoxicity against a panel of human tumor cell lines. The ac etate of (-)-ampelopsin A (12) showed potent and selective cytotoxic activi ty with ED50 values of 0.6, 0.7 and 2.0 mu g/mL against KB, 1A9 and MCF-7 c ells, respectively. Hopeaphenol (10) and pallidol hexaacetate (13) also sho wed significant cytotoxicity against KB cells with ED50 values of 1.2 and 1 .6 mu g/mL, respectively. (C) 1999 Elsevier Science Ltd. All rights reserve d.