Viruses and apoptosis

Citation
A. Roulston et al., Viruses and apoptosis, ANN R MICRO, 53, 1999, pp. 577-628
Citations number
338
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Microbiology
Journal title
ANNUAL REVIEW OF MICROBIOLOGY
ISSN journal
0066-4227 → ACNP
Volume
53
Year of publication
1999
Pages
577 - 628
Database
ISI
SICI code
0066-4227(1999)53:<577:VAA>2.0.ZU;2-B
Abstract
Successful viral replication requires not only the efficient production and spread of progeny, but also evasion of host defense mechanisms that limit replication by killing infected cells. In addition to inducing immune and i nflammatory responses, infection by most viruses triggers apoptosis or prog rammed cell death of the infected cell. This cell response often results as a compulsory or unavoidable byproduct of the action of critical viral repl icative functions. In addition, some viruses seem to use apoptosis as a mec hanism of cell killing and virus spread. In both cases, successful replicat ion relies on the ability of certain viral products to block or delay apopt osis until sufficient progeny have been produced. Such proteins target a va riety of strategic points in the apoptotic pathway. In this review we summa rize the great amount of recent information on viruses and apoptosis and of fer insights into how this knowledge may be used for future research and no vel therapies.