Giant viruses infecting algae

Citation
Jl. Van Etten et Rh. Meints, Giant viruses infecting algae, ANN R MICRO, 53, 1999, pp. 447-494
Citations number
210
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Microbiology
Journal title
ANNUAL REVIEW OF MICROBIOLOGY
ISSN journal
0066-4227 → ACNP
Volume
53
Year of publication
1999
Pages
447 - 494
Database
ISI
SICI code
0066-4227(1999)53:<447:GVIA>2.0.ZU;2-P
Abstract
Paramecium bursaria chlorella virus (PBCV-1) is the prototype of a family o f large, icosahedral, plaque-forming, double-stranded-DNA-containing viruse s that replicate in certain unicellular, eukaryotic chlorella-like green al gae. DNA sequence analysis of its 330, 742-bp genome leads to the predictio n that this phycodnavirus has 376 protein-encoding genes and 10 transfer RN A genes. The predicted gene products of similar to 40% of these genes resem ble proteins of known function. The chlorella viruses have other features t hat distinguish them from most viruses, in addition to their large genome s ize. These features include the following: (a) The viruses encode multiple DNA methyltransferases and DNA site-specific endonucleases; (b) PBCV-1 enco des at least part, if not the entire machinery to glycosylate its proteins; (c) PBCV-1 has at least two types of introns-a self-splicing intron in a t ranscription factor-like gene and a splicesomal processed type of intron in its DNA polymerase gene. Unlike the chlorella viruses, large double-strand ed-DNA-containing viruses that infect marine, filamentous brown algae have a circular genome and a lysogenic phase in their life cycle.