Constructing polyketides: From collie to combinatorial biosynthesis

Authors
Bentley, R Bennett, JW
Citation
R. Bentley et Jw. Bennett, Constructing polyketides: From collie to combinatorial biosynthesis, ANN R MICRO, 53, 1999, pp. 411-446
Citations number
176
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Microbiology
Journal title
ANNUAL REVIEW OF MICROBIOLOGY
ISSN journal
0066-4227 → ACNP
Volume
53
Year of publication
1999
Pages
411 - 446
Database
ISI
SICI code
0066-4227(1999)53:<411:CPFCTC>2.0.ZU;2-V
Abstract
In a new golden age, polyketides are investigated and manipulated with the tools of molecular biology and genetics; hybrid polyketides can be produced . Pharmaceutical companies hope to find new and useful polyketide products, including antibiotics, anthelminthics, and immunosuppressants. This review describes the past developments (largely chemical) on which the present in vestigations are based, attempts to make sense of the expanding scope of po lyketides, looks at the shifting research focus around polyketides, present s a working definition in biosynthetic terms, and takes note of recent work in combinatorial biosynthesis. Also discussed is the failure of the classi cal enzymological approach to polyketide biosynthesis.