Integrating DNA: Transposases and retroviral integrases

Citation
L. Haren et al., Integrating DNA: Transposases and retroviral integrases, ANN R MICRO, 53, 1999, pp. 245-281
Citations number
185
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Microbiology
Journal title
ANNUAL REVIEW OF MICROBIOLOGY
ISSN journal
0066-4227 → ACNP
Volume
53
Year of publication
1999
Pages
245 - 281
Database
ISI
SICI code
0066-4227(1999)53:<245:IDTARI>2.0.ZU;2-Q
Abstract
Transposable elements appear quite disparate in their organization and in t he types of genetic rearrangements they promote. In spite of this diversity , retroviruses and many transposons of both prokaryotes and eukaryotes show clear similarities in the chemical reactions involved in their transpositi on. This is reflected in the enzymes, integrases and transposases, that cat alyze these reactions and that are essential for the mobility of the elemen ts. In this chapter, we examine the structure-function relationships betwee n these enzymes and the different ways in which the individual steps are as sembled to produce a complete transposition cycle.