The induction of apoptosis by bacterial pathogens

Citation
Y. Weinrauch et A. Zychlinsky, The induction of apoptosis by bacterial pathogens, ANN R MICRO, 53, 1999, pp. 155-187
Citations number
263
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Microbiology
Journal title
ANNUAL REVIEW OF MICROBIOLOGY
ISSN journal
0066-4227 → ACNP
Volume
53
Year of publication
1999
Pages
155 - 187
Database
ISI
SICI code
0066-4227(1999)53:<155:TIOABB>2.0.ZU;2-3
Abstract
Apoptosis is a highly regulated process of cell death that is required for the development and homeostasis of multicellular organisms. In contrast to necrosis, apoptosis eliminates individual cells without inducing an inflamm atory response. Activation or prevention of cell death could be a critical factor in the outcome of an infection. Programmed cell death has been obser ved as a response to infection by a wide range of animal and plant pathogen s and is mediated by an array of pathogen-encoded virulence determinants. P athogen-induced modulation of the host cell-death pathway may serve to elim inate key immune cells or evade host defenses that can act to limit the inf ection. Alternatively, suppression of the death pathway may facilitate the proliferation of intracellular pathogens.