Addiction modules and programmed cell death and antideath in bacterial cultures

Citation
H. Engelberg-kulka et G. Glaser, Addiction modules and programmed cell death and antideath in bacterial cultures, ANN R MICRO, 53, 1999, pp. 43-70
Citations number
121
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Microbiology
Journal title
ANNUAL REVIEW OF MICROBIOLOGY
ISSN journal
0066-4227 → ACNP
Volume
53
Year of publication
1999
Pages
43 - 70
Database
ISI
SICI code
0066-4227(1999)53:<43:AMAPCD>2.0.ZU;2-#
Abstract
In bacteria, programmed cell death is mediated through "addiction modules" consisting of two genes. The product of the second gene is a stable toxin, whereas the product of the first is a labile antitoxin. Here we extensively review what is known about those modules that are borne by one of a number of Escherichia coli extrachromosomal elements and are responsible for the postsegregational killing effect. We focus on a recently discovered chromos omally borne regulatable addiction module in E. coli that responds to nutri tional stress and also on an antideath gene of the E. coli bacteriophage la mbda. We consider the relation of these two to programmed cell death and an tideath in bacterial cultures. Finally, we discuss the similarities between basic features of programmed cell death and antideath in both prokaryotes and eukaryotes and the possibility that they share a common evolutionary or igin.