Transformation of leukocytes by Theileria parva and T-annulata

Citation
D. Dobbelaere et V. Heussler, Transformation of leukocytes by Theileria parva and T-annulata, ANN R MICRO, 53, 1999, pp. 1
Citations number
197
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Microbiology
Journal title
ANNUAL REVIEW OF MICROBIOLOGY
ISSN journal
0066-4227 → ACNP
Volume
53
Year of publication
1999
Database
ISI
SICI code
0066-4227(1999)53:<1:TOLBTP>2.0.ZU;2-J
Abstract
Theileria parva and T annulata provide intriguing models for the study of p arasite-host interactions. Both parasites possess the unique property of be ing able to transform the cells they infect; T. parva transforms T and B ce lls, whereas T annulata affects B cells and monocytes/macrophages. Parasiti zed cells do not require antigenic stimulation or exogenous growth factors and acquire the ability to proliferate continuously. In vivo, parasitized c ells undergo clonal expansion and infiltrate both lymphoid and non-lymphoid tissues of the infected host. Theileria-induced transformation is entirely reversible and is accompanied by the expression of a wide range of differe nt lymphokines and cytokines, some of which may contribute to proliferation or may enhance spread and survival of the parasitized cell in the host. Th e presence of the parasite in the host-cell cytoplasm modulates the state o f activation of a number of signal transduction pathways. This, in turn, le ads to the activation of transcription factors, including nuclear factor-ka ppa B, which appear to be essential for the survival of Theileria-transform ed T cells.