IS PARTICLE-BEAM AN UP-TO-DATE LC-MC INTERFACE - STATE-OF-THE-ART ANDPERSPECTIVES

Authors
Citation
A. Cappiello, IS PARTICLE-BEAM AN UP-TO-DATE LC-MC INTERFACE - STATE-OF-THE-ART ANDPERSPECTIVES, Mass spectrometry reviews, 15(5), 1996, pp. 283-296
Citations number
30
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Spectroscopy
Journal title
ISSN journal
0277-7037
Volume
15
Issue
5
Year of publication
1996
Pages
283 - 296
Database
ISI
SICI code
0277-7037(1996)15:5<283:IPAULI>2.0.ZU;2-#
Abstract
The particle beam liquid chromatography-mass spectrometry interface, d eveloped more than ten years ago, has withstood the assault of several new soft ionization-based interfaces, and it is still largely used wo rldwide. The particle beam has widened the possibility for many HPLC-a menable compounds to be ionized under electron ionization conditions w ithout any appreciable thermal degradation. This feature is not of sec ondary importance in several ''small'' molecules applications, where t he analytes can be easily identified and their spectra matched with th ose collected in literature. The task of separating any solute from a liquid mobile phase is carried our very efficiently by the particle be am interface, and the only real limitation is found at the moment of t he solute vaporization in the ion source; therefore, the principle of particle formation for sample transfer into a mass spectrometer could be extended profitably to other ionization techniques. (C) 1997 John W iley & Sons, Inc.