Two target regions of allelic loss on chromosome 9 in urinary-bladder cancer

Citation
K. Ohgaki et al., Two target regions of allelic loss on chromosome 9 in urinary-bladder cancer, JPN J CANC, 90(9), 1999, pp. 957-964
Citations number
52
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
JAPANESE JOURNAL OF CANCER RESEARCH
ISSN journal
0910-5050 → ACNP
Volume
90
Issue
9
Year of publication
1999
Pages
957 - 964
Database
ISI
SICI code
0910-5050(199909)90:9<957:TTROAL>2.0.ZU;2-5
Abstract
Allelic losses on chromosome 9 are common in a wide variety of human tumors ; moreover, two predisposing loci for some inherited cancer syndromes, i.e. , familial malignant melanoma and Gorlin syndrome, have been identified on this chromosome. To define the location of putative tumor suppressor genes involved in cancer of the urinary bladder, 85 bladder cancers were examined for allelic loss at 18 microsatellite loci on chromosome 9. Correlations w ere also sought between loss of heterozygosity on chromosome 9 and several clinicopathological parameters. Allelic loss was observed in 54 of the tumo rs (64%) and deletion mapping identified two target regions; one at an inte rval on 9p21 flanked by D9S736 and D9S165, and the other at an interval on 9q31-34 flanked by D9S58 and D9S61, No subtle mutation was detected in the PTCH gene which lies in the latter interval. Allelic loss on chromosome 9 w as observed frequently in low grade and non-invasive tumors as well as in t umors of more advanced phenotype, Inactivation of tumor suppressor genes ly ing in either of two regions of common deletion identified on chromosome 9 might affect carcinogenic mechanisms at an early stage of tumor development in the urinary bladder.