Anti-Yo positive paraneoplastic cerebellar degeneration associated with ovarian carcinoma: Case report and review of the literature

Citation
Ym. Cao et al., Anti-Yo positive paraneoplastic cerebellar degeneration associated with ovarian carcinoma: Case report and review of the literature, GYNECOL ONC, 75(1), 1999, pp. 178-183
Citations number
45
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Reproductive Medicine
Journal title
GYNECOLOGIC ONCOLOGY
ISSN journal
0090-8258 → ACNP
Volume
75
Issue
1
Year of publication
1999
Pages
178 - 183
Database
ISI
SICI code
0090-8258(199910)75:1<178:APPCDA>2.0.ZU;2-T
Abstract
Paraneoplastic cerebellar degeneration (PCD) is a rare nonmetastatic neurol ogical complication in cancer patients. Anti-Yo is one of the anti-onconeur al antibodies found in PCD patients. It is believed that anti-Yo occurs alm ost always in women and is most likely associated with gynecologic or breas t cancers, although exceptions exist. Here we report a PCD patient with ova rian cancer having high-titer anti-Yo, The acute onset of her PCD symptoms mimicked that of a stroke, Her ovarian cancer tissue contained abundant pla sma cells and lymphocytes. After a thorough review of the literature, we pr opose a schematic hypothesis for the autoimmune pathogenesis of PCD, Despit e anecdotal case reports of neurological improvement with different combina tions of treatment, including IVIg, there is still no definitely effective treatment for PCD. Further research on the pathogenesis of PCD may lead to more effective therapies. (C) 1999 Academic Press.