Similar effect of revascularization on technetium-99m sestamibi and 15-(p-iodophenyl)pentadecanoic acid uptake in myocardial infarction patients

Citation
S. Bendel et al., Similar effect of revascularization on technetium-99m sestamibi and 15-(p-iodophenyl)pentadecanoic acid uptake in myocardial infarction patients, EUR J NUCL, 26(10), 1999, pp. 1304-1309
Citations number
27
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Radiology ,Nuclear Medicine & Imaging","Medical Research Diagnosis & Treatment
Journal title
EUROPEAN JOURNAL OF NUCLEAR MEDICINE
ISSN journal
0340-6997 → ACNP
Volume
26
Issue
10
Year of publication
1999
Pages
1304 - 1309
Database
ISI
SICI code
0340-6997(199910)26:10<1304:SEOROT>2.0.ZU;2-M
Abstract
To study its usefulness as a tracer for assessment of the perfusion and via bility of myocardium, 15(p-iodophenyl)pentadecanoic acid (IPPA) was compare d with technetium-99m sestamibi (MIBI). Dual-tracer single-photon emission tomography rest imaging was performed no more than 2 months before and 3 mo nths after coronary artery bypass grafting in 28 patients with previous ant erior (n=13) or inferior (n=55 infarction, The size of MIBI and IPPA defect s decreased from 14%+/-12% and 13%+/-9% to 10%+/-11% and 9%+/-7%, respectiv ely (P<0.001 for both), The MIBI uptake increased in the infarct zones fi o m 35%+/-11% to 43%+/-8% (P<0.001), and in the peri-infarct zones from 50%+/ -11% to 55%+/-10% (P<0.05). The IPPA uptake increased in the infarct zones from 37%+11% to 14%+/-13% (P<0.001), and in the peri-infarct zones from 51% +/-11% to 57%+/-12% (P<0.05). In nine patients with improved regional echoc ardiographic wall motion score after bypass surgery, the pre-operative upta ke values of both MIBI and IPPA in the infarct and peri-infarct zones were on average slightly but not significantly higher than in 19 patients with n o observed improvement in regional wall motion score. In patients with impr oved regional wall motion, the MIBI scans and the IPPA scans showed (non-si gnificant) decreases in defect size and increases in infarct and peri-infar ct zone uptake after bypass surgery. Similar tin some cases significant) ch anges were observed in the patients without improvement in wall motion. Thu s IPPA and MIBI provided similar information about perfusion and viability in pre- and postoperative evaluation of patients with clinically evident my ocardial infarction and with normal global ejection fraction. Regardless of the tracer used, the resolution capability of the dual-tracer method with a rest imaging protocol was not sufficient to differentiate viable from non viable infarction defects in unselected individual patients with a normal e jection fraction.