Westernization of Chinese adults and increased subclinical atherosclerosis

Citation
Ks. Woo et al., Westernization of Chinese adults and increased subclinical atherosclerosis, ART THROM V, 19(10), 1999, pp. 2487-2493
Citations number
38
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cardiovascular & Hematology Research
Journal title
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY
ISSN journal
1079-5642 → ACNP
Volume
19
Issue
10
Year of publication
1999
Pages
2487 - 2493
Database
ISI
SICI code
1079-5642(199910)19:10<2487:WOCAAI>2.0.ZU;2-Y
Abstract
Cardiovascular event rates are much lower in China compared with developed countries. "Westernization" of diet and lifestyle in the Chinese, however, may lead to an increased prevalence of atherosclerosis-related diseases. Be cause carotid intima-media thickness (IMT) is a marker of subclinical ather osclerosis, we examined IMT and vascular risk profile in community-based gr oups of rural Chinese, Westernized urban Chinese, and urban whites. Mean IM T of the common carotid artery was measured in 348 healthy adults, aged 42/-13 years (range 21 to 71 years); 116 subjects from rural China, 116 urban Chinese subjects living in Hong Kong or in Australia, and 116 urban Caucas ians living in Australia. These 3 groups were matched for age, sex, and cig arette smoke exposure. Urban Chinese subjects had slightly better risk fact or profile (higher HDL-cholesterol and lower blood pressure) compared with rural Chinese subjects. Despite this, however, the mean IMT was lowest in r ural Chinese (0.50+/-0.10 mm), intermediate in urban Chinese (0.56+/-0.12 m m), and highest in urban whites (0.64+/-0.13 mm) (P<0.001 for comparisons b etween all groups). These differences in IMT were not altered after adjustm ent for the major traditional cardiovascular risk factors (serum lipids, sm oking, and blood pressure or for body mass index). The influence of vascula r risk factors on atherosclerosis between urban versus rural Chinese subjec ts was studied by multivariate regression models and by comparing the steep ness of regression slopes between risk factors and IMT in the subject group s. The effects of smoking, HDL-cholesterol, and triglycerides on IMT were s ignificantly greater in the urban compared with the rural Chinese (P<0.01). These data suggest that Westernization of Chinese subjects is associated w ith greater susceptibility to the pro-atherogenic effects of traditional va scular risk factors, such as lipids and smoking, and with evidence of incre ased IMT as a marker of subclinical atherosclerosis.