D. Ferroud et al., Synthesis and biological evaluation of coumarincarboxylic acids as inhibitors of gyrase B. L-rhamnose as an effective substitute for L-noviose, BIOORG MED, 9(19), 1999, pp. 2881-2886
A series of novobiocin-like coumarincarboxylic acids has been prepared bear
ing the L-rhamnosyl moiety as the sugar portion of the molecule. The simila
r DNA gyrase inhibitory activity of the novel class of coumarins to that of
novobiocin demonstrates that L-rhamnose can effectively replace L-noviose.
Introduction of alkyl side-chains at C-5 of coumarin leads to improved in
vitro antibacterial properties in the novel series. (C) 1999 Elsevier Scien
ce Ltd. All rights reserved.