Synthesis and biological evaluation of coumarincarboxylic acids as inhibitors of gyrase B. L-rhamnose as an effective substitute for L-noviose

Citation
D. Ferroud et al., Synthesis and biological evaluation of coumarincarboxylic acids as inhibitors of gyrase B. L-rhamnose as an effective substitute for L-noviose, BIOORG MED, 9(19), 1999, pp. 2881-2886
Citations number
27
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960-894X → ACNP
Volume
9
Issue
19
Year of publication
1999
Pages
2881 - 2886
Database
ISI
SICI code
0960-894X(19991004)9:19<2881:SABEOC>2.0.ZU;2-5
Abstract
A series of novobiocin-like coumarincarboxylic acids has been prepared bear ing the L-rhamnosyl moiety as the sugar portion of the molecule. The simila r DNA gyrase inhibitory activity of the novel class of coumarins to that of novobiocin demonstrates that L-rhamnose can effectively replace L-noviose. Introduction of alkyl side-chains at C-5 of coumarin leads to improved in vitro antibacterial properties in the novel series. (C) 1999 Elsevier Scien ce Ltd. All rights reserved.