Modified Dakin's solution for cutaneous vibrio infections

Citation
Bj. Wilhelmi et al., Modified Dakin's solution for cutaneous vibrio infections, ANN PL SURG, 43(4), 1999, pp. 386-389
Citations number
26
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Surgery
Journal title
ANNALS OF PLASTIC SURGERY
ISSN journal
0148-7043 → ACNP
Volume
43
Issue
4
Year of publication
1999
Pages
386 - 389
Database
ISI
SICI code
0148-7043(199910)43:4<386:MDSFCV>2.0.ZU;2-C
Abstract
Vibrio species, specifically Vibrio vulnificus, are known to be endemic to warm saltwater environments. As a human pathogen they are capable of causin g severe, progressive, necrotizing infections. The lesions are bullous in n ature and often require wide surgical debridement due to the aggressiveness of this organism. The literature supports prophylactic antibiotic therapy for those with preexisting hepatic dysfunction or immunocompromise. The aut hors routinely implement prophylactic antibiotic coverage with doxycycline 100 mg every 12 hours for vibrio in patients with wounds exposed to or acqu ired in saltwater. In addition, they institute topical therapy with 0.025% sodium hypochlorite solution (modified Dakin's), based on their in vitro st udy of vibrio sensitivity to antimicrobials, Over the past 2 years, the aut hors have treated 10 patients with this protocol for cutaneous vibrio infec tions confirmed by quantitative cultures. None of these patients experience d progression of infection requiring operative debridement-contrary to the aggressive nature of this organism documented in other reports.