Human platelet alloantigen (HPA)5a/b mismatch decreases disease-free survival in unrelated bone marrow transplantation

Citation
T. Juji et al., Human platelet alloantigen (HPA)5a/b mismatch decreases disease-free survival in unrelated bone marrow transplantation, TISSUE ANTI, 54(3), 1999, pp. 229-234
Citations number
21
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Medical Research Diagnosis & Treatment
Journal title
TISSUE ANTIGENS
ISSN journal
0001-2815 → ACNP
Volume
54
Issue
3
Year of publication
1999
Pages
229 - 234
Database
ISI
SICI code
0001-2815(199909)54:3<229:HPA(MD>2.0.ZU;2-9
Abstract
Matching of human platelet alloantigen (HPA) systems 2-6 was retrospectivel y investigated in 715 unrelated bone marrow transplantations. Of the five H PA systems studied, HPA-5 mismatching was found to have a significant effec t on the disease-free survival rate of recipients following transplantation in the HLA-A, -B, -C, and -DR allele-matched donor-recipient pairs. The ef fect of the HPA-5 mismatch was most significant in the recipient group poss essing the HLA haplotype A*2402-B*5201, which is a highly frequent haplotyp e among the Japanese population. However, the probability of development of acute graft-versus-host disease (GVHD) was not increased significantly by the HPA-5 mismatching. These findings suggest that the HPA-5 mismatching de creases the recipient's survival by a mechanism different from that in the case of mismatching of minor antigens found often in transplant recipients developing GVHD.