Sensorimotor polyneuropathy associated with chronic lymphocytic leukemia, IgM antigangliosides antibody and human T-cell leukemia virus I infection

Citation
Y. Mitsui et al., Sensorimotor polyneuropathy associated with chronic lymphocytic leukemia, IgM antigangliosides antibody and human T-cell leukemia virus I infection, MUSCLE NERV, 22(10), 1999, pp. 1461-1465
Citations number
25
Language
INGLESE
art.tipo
Article
Categorie Soggetti
da verificare
Journal title
MUSCLE & NERVE
ISSN journal
0148-639X → ACNP
Volume
22
Issue
10
Year of publication
1999
Pages
1461 - 1465
Database
ISI
SICI code
0148-639X(199910)22:10<1461:SPAWCL>2.0.ZU;2-B
Abstract
A 65-year-old man presented with a sensorimotor polyneuropathy associated w ith B-cell chronic lymphocytic leukemia (CLL) and immunoglobulin M (IgM) an tibody to various gangliosides. Etectrophysiological studies denoted signif icant abnormalities of motor and sensory nerve conduction. Although the pat hology of sural nerve biopsy looked minimally affected, immunohistochemical studies showed specific binding of IgM to the human peripheral nerve. Our patient also had high titer of antibody to human T-cell leukemia virus I (H TLV-I) in both serum and cerebrospinal fluid (CSF), which might activate B- cell-mediated immunity and facilitate the production of IgM antibody. The o ther unique feature is the reactivity of antibody to gangliosides. The pati ent had IgM antibody reactivities to gangliosides with disialosyl residue s uch as GT1b, GQ1b and GD3, but not to GD1b. IgM antibody to gangliosides wi th disialosyl residue has been reported in ataxic symptoms, but our patient failed to demonstrate ataxia. Without reactivity to GD1b, sensory ataxic n europathy might not develop even in the presence of antibody reactive to ot her gangliosides with disialosyl residue. (C) 1999 John Wiley & Sons, Inc.