Phytol induces programmed cell death in human lymphoid leukemia Molt 4B cells

Citation
T. Komiya et al., Phytol induces programmed cell death in human lymphoid leukemia Molt 4B cells, INT J MOL M, 4(4), 1999, pp. 377-380
Citations number
19
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Medical Research General Topics
Journal title
INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
ISSN journal
1107-3756 → ACNP
Volume
4
Issue
4
Year of publication
1999
Pages
377 - 380
Database
ISI
SICI code
1107-3756(199910)4:4<377:PIPCDI>2.0.ZU;2-8
Abstract
The exposure of human lymphoid leukemia Molt 4B cells to phytol which was i solated from Lolium multiflorum Lam and identified by MS, and H-1- and C-13 -NMR, led to both growth inhibition and the induction of programmed cell de ath (apoptosis). Morphological change showing apoptotic bodies was observed in the cells treated with phytol. The fragmentation by phytol of DNA to ol igonucleosomal-sized fragments that are characteristics of apoptosis was ob served to be concentration- and time-dependent. These findings suggest that growth inhibition by phytol of Molt 4B cells results from the induction of apoptosis in the cells.