Impaired thymopoietic potential of immature CD3(-)CD4(+)CD8(-) T cell precursors from SIV-infected rhesus monkeys

Citation
K. Neben et al., Impaired thymopoietic potential of immature CD3(-)CD4(+)CD8(-) T cell precursors from SIV-infected rhesus monkeys, INT IMMUNOL, 11(9), 1999, pp. 1509-1518
Citations number
35
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Immunology
Journal title
INTERNATIONAL IMMUNOLOGY
ISSN journal
0953-8178 → ACNP
Volume
11
Issue
9
Year of publication
1999
Pages
1509 - 1518
Database
ISI
SICI code
0953-8178(199909)11:9<1509:ITPOIC>2.0.ZU;2-3
Abstract
Immature thymocyte subpopulations were examined for their capacity to diffe rentiate in a newly developed xenogeneic monkey-mouse fetal thymus organ cu lture (FTOC) system. We provide evidence for impaired precursor function of CD3(-)CD4(+)CD8(-) thymocytes after in vivo infection with SIVmac251 as in dicated by a reduced cell number per FTOC and a lower percentage of thymocy tes with more mature phenotypes. Addition of recombinant SIV glycoprotein 1 20 (rgp120) also resulted in a dose-dependent impairment of T cell maturati on in FTOC. The data suggest that in patients infected with HIV, T cell mat uration and thus replenishment of peripheral pools may be compromised as a result of intrathymic infection or circulating viral gp120.