Ag. Quiroga et al., Synthesis and characterization of Pd(II) and Pt(II) complexes of p-isopropylbenzaldehyde N-protected thiosemicarbazones. Cytotoxic activity against ras-transformed cells, J INORG BIO, 75(4), 1999, pp. 293-301
Cytotoxicity tests in tumor cells sensitive to cis-DDP (HL-60, JURKAT,Hela
and 3T3) and in tumor cells transformed by ras oncogenes and resistant to c
is-DDP (Pam 212-ras) show that cyclometallated complexes 1a [Pd(p-is.TSCN-N
HMe) ](4,) 2b [Pt(p-is.TSCN-NMe2)](4) and 4a [Pd(p-is.TSCN-NHex) ](4) may b
e endowed with specific cytotoxic properties. In fact, these three novel me
tal-thiosemicarbazone compounds kill Pam 212-ras cells through apoptosis in
duction. These results. together with others recently published, indicate t
hat the design and synthesis of metallated-thiosemicarbazone compounds may
lead to the discovery of novel antitumor agents able to circumvent cis-DDP
resistance, in particular tumor cell lines. (C) 1999 Elsevier Science Inc.
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