Synthesis and characterization of Pd(II) and Pt(II) complexes of p-isopropylbenzaldehyde N-protected thiosemicarbazones. Cytotoxic activity against ras-transformed cells

Citation
Ag. Quiroga et al., Synthesis and characterization of Pd(II) and Pt(II) complexes of p-isopropylbenzaldehyde N-protected thiosemicarbazones. Cytotoxic activity against ras-transformed cells, J INORG BIO, 75(4), 1999, pp. 293-301
Citations number
44
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Biochemistry & Biophysics","Inorganic & Nuclear Chemistry
Journal title
JOURNAL OF INORGANIC BIOCHEMISTRY
ISSN journal
0162-0134 → ACNP
Volume
75
Issue
4
Year of publication
1999
Pages
293 - 301
Database
ISI
SICI code
0162-0134(19990715)75:4<293:SACOPA>2.0.ZU;2-9
Abstract
Cytotoxicity tests in tumor cells sensitive to cis-DDP (HL-60, JURKAT,Hela and 3T3) and in tumor cells transformed by ras oncogenes and resistant to c is-DDP (Pam 212-ras) show that cyclometallated complexes 1a [Pd(p-is.TSCN-N HMe) ](4,) 2b [Pt(p-is.TSCN-NMe2)](4) and 4a [Pd(p-is.TSCN-NHex) ](4) may b e endowed with specific cytotoxic properties. In fact, these three novel me tal-thiosemicarbazone compounds kill Pam 212-ras cells through apoptosis in duction. These results. together with others recently published, indicate t hat the design and synthesis of metallated-thiosemicarbazone compounds may lead to the discovery of novel antitumor agents able to circumvent cis-DDP resistance, in particular tumor cell lines. (C) 1999 Elsevier Science Inc. All rights reserved.