Enhanced expression of Tie2, its ligand angiopoietin-1, vascular endothelial growth factor, and CD31 in human non-small cell lung carcinomas

Citation
M. Takahama et al., Enhanced expression of Tie2, its ligand angiopoietin-1, vascular endothelial growth factor, and CD31 in human non-small cell lung carcinomas, CLIN CANC R, 5(9), 1999, pp. 2506-2510
Citations number
37
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Oncology
Journal title
CLINICAL CANCER RESEARCH
ISSN journal
1078-0432 → ACNP
Volume
5
Issue
9
Year of publication
1999
Pages
2506 - 2510
Database
ISI
SICI code
1078-0432(199909)5:9<2506:EEOTIL>2.0.ZU;2-N
Abstract
Expression of angiogenesis-associated genes was compared in 32 primary non- small cell lung carcinoma samples (14 adenocarcinomas, 17 squamous cell car cinomas, and 1 large cell carcinoma) and paired adjacent noncancerous lung tissues using a multiprobe RNase protection assay. Levels of Tie2, angiopoi etin (Ang)-1, vascular endothelial growth factor (VEGF), and CD31 mRNAs wer e higher in cancers than in adjacent noncancerous tissues, in contrast to t he fms-like tyrosine kinase (Flt)-1, Flt-4, Tiel, thrombin receptor, endogl in, and VEGF-C, for which no differences were evident. Overexpression did n ot seem to differ with histological type and pathological stage. Significan t positive correlations were found between mRNA expression of Ang-l and tho se of Tie2 and CD31, and that of VEGF and those of Flt-1 and CD31, These fi ndings suggest that Ang-1 and VEGF are important angiogenic factors in huma n non-small cell lung carcinomas.