Application of macroautoradiography and instantimage in radiopharmaceutical research

Citation
Jj. Hwang et al., Application of macroautoradiography and instantimage in radiopharmaceutical research, J RAD NUCL, 241(3), 1999, pp. 581-587
Citations number
20
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Inorganic & Nuclear Chemistry
Journal title
JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY
ISSN journal
0236-5731 → ACNP
Volume
241
Issue
3
Year of publication
1999
Pages
581 - 587
Database
ISI
SICI code
0236-5731(199909)241:3<581:AOMAII>2.0.ZU;2-3
Abstract
The evaluation of the pharmacokinetics of pure, beta radiopharmaceuticals i s not possible with scintigraphy. Both whole-body autoradiography (WBAR) an d Packard Instantimager, a device for rapid imaging, were used to study the whole body distribution of gamma- and beta-emitting radionuclides (Tc-99m- MDp, Tc-99m-sulfur colloid, or Re-188-HEDP), and results obtained from both methods were compared. The biodistribution of 99mTc-MDp and Re-188-HEDP we re seen mainly in bones including skull, spine, and vertebrae of spine and cardiac and skeletal muscles. The Tc-99m-sulfur colloid localized in liver, bone marrow, and spleen. The resolution of WBAR is superior than that of P ackard Instantimager. However, the advantage of Packard Instantimager is th at rapid imaging within few minutes is possible with it, while WEAR imaging requires several hours to days.