Prolactin involvement in breast cancer

Authors
Citation
Bk. Vonderhaar, Prolactin involvement in breast cancer, ENDOCR-R CA, 6(3), 1999, pp. 389-404
Citations number
158
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Endocrynology, Metabolism & Nutrition
Journal title
ENDOCRINE-RELATED CANCER
ISSN journal
1351-0088 → ACNP
Volume
6
Issue
3
Year of publication
1999
Pages
389 - 404
Database
ISI
SICI code
1351-0088(199909)6:3<389:PIIBC>2.0.ZU;2-N
Abstract
Normal development and differentiation of the mammary gland are profoundly influenced by prolactin (PRL). In rodent mammary cancer PRL plays a well de fined role, but its role in human breast cancer has not been appreciated un til recently. It is now clear that breast tissue, both normal and malignant , is a significant source of extrapituitary PRL. Thus an autocrine/paracrin e role of PRL in human breast cancer may be invoked. Both PRL and PRL recep tor mRNA are expressed in the vast majority of breast cancer biopsies indep endent of estrogen and progesterone receptor status, An autocrine/paracrine PRL acting in human breast cancer requires that this hormone's action be b locked at the cellular level, as opposed to suppressing the synthesis and s ecretion of pituitary PRL. Mutants of PRL or human growth hormone are being explored which act as selective PRL antagonists. In addition, tamoxifen ha s been shown to act locally at the target tissue by binding directly to the PRL receptor and thus inhibiting PRL's action. These strategies may have c linical relevance in treating PRL-responsive human breast cancer.