Increased airway responsiveness to acetaldehyde in asthmatic subjects withalcohol-induced bronchoconstriction

Citation
M. Fujimura et al., Increased airway responsiveness to acetaldehyde in asthmatic subjects withalcohol-induced bronchoconstriction, EUR RESP J, 14(1), 1999, pp. 19-22
Citations number
15
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cardiovascular & Respiratory Systems","da verificare
Journal title
EUROPEAN RESPIRATORY JOURNAL
ISSN journal
0903-1936 → ACNP
Volume
14
Issue
1
Year of publication
1999
Pages
19 - 22
Database
ISI
SICI code
0903-1936(199907)14:1<19:IARTAI>2.0.ZU;2-Q
Abstract
Bronchial responsiveness to acetaldehyde, a main factor in alcohol-induced bronchoconstriction, and methacholine were compared between 10 subjects wit h alcohol-induced bronchoconstriction and 16 asthmatic subjects without alc ohol sensitivity. In the alcohol-sensitive group, the geometric mean (geometric SEM (GSEM)) o f the provocative concentration of methacholine (PC20,meth) and acetaldehyd e (PC20,acet) causing a 20% fall in forced expiratory volume in one second were 0.947 mg.mL(-1) (GSEM 0.139) and 21.0 mg.mL(-1) (GSEM 0.112), respecti vely, which were not significantly different from those in the nonalcohol-s ensitive group, which were 0.634 mg.mL(-1) (GSEM 0.115) and 31.7 mg.mL(-1) (GSEM 0.077), respectively. The ratio of airway responsiveness to acetaldeh yde relative to methacholine (log PC20,acet/PC20,meth) was 1,345+/- 0.093 ( mean+/-SEM) in the alcohol-sensitive group, which was significantly differe nt from the value of 1.699+/-0.059 in the nonalcohol-sensitive group (p=0.0 025). A significant correlation was observed between PC20,meth and PC20,ace t in both the alcohol-sensitive group (r=0.742, p=0.0115) and nonsensitive group (r=0.882, p<0.0001). In conclusion, the airways of asthmatic subjects with alcohol-induced bronc ho-constriction have a selective hyperresponsiveness to acetaldehyde.