Possible association of human leucocyte antigen DR1 with delayed sleep phase syndrome

Citation
H. Hohjoh et al., Possible association of human leucocyte antigen DR1 with delayed sleep phase syndrome, PSY CLIN N, 53(4), 1999, pp. 527-529
Citations number
11
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Clinical Psycology & Psychiatry
Journal title
PSYCHIATRY AND CLINICAL NEUROSCIENCES
ISSN journal
1323-1316 → ACNP
Volume
53
Issue
4
Year of publication
1999
Pages
527 - 529
Database
ISI
SICI code
1323-1316(199908)53:4<527:PAOHLA>2.0.ZU;2-G
Abstract
The study investigated the human leucocyte antigen (HLA), types A, B and DR , of 42 patients with delayed sleep phase syndrome (DSPS) and compared the frequencies of the antigens with those in 117 healthy controls. The compari son revealed that the gene frequencies and positivities of HLA-A, -B and -D R, except for DR1, had no significant differences between the patients and controls. The frequency of HLA-DR1 was increased in the DSPS patients as co mpared with that in the healthy controls (P = 0.0069 in positivity). Althou gh the corrected P-value (0.069) for multiple comparisons almost reached th e significance level, the results indicated a possible association of the H LA-DR1 antigen with DSPS. This study suggests that there are genetic predis positions to DSPS.