Correlation between magnetic resonance imaging and clinical profiles of periventricular leukomalacia

Citation
S. Fujimoto et al., Correlation between magnetic resonance imaging and clinical profiles of periventricular leukomalacia, TOH J EX ME, 188(2), 1999, pp. 143-151
Citations number
17
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Medical Research General Topics
Journal title
TOHOKU JOURNAL OF EXPERIMENTAL MEDICINE
ISSN journal
0040-8727 → ACNP
Volume
188
Issue
2
Year of publication
1999
Pages
143 - 151
Database
ISI
SICI code
0040-8727(199906)188:2<143:CBMRIA>2.0.ZU;2-Z
Abstract
Magnetic resonance imaging (MRI) findings of 70 children with periventricul ar leukomalacia (PVL), examined between 1 year 2 months and 8 years of age (mean: 2 years 4 months of age), were analysed. Neurological assessments we re made between 1 year 3 months and 15 years (mean: 4 years 9 months). The possible correlations between MRI findings and clinical profiles of PVL wer e investigated using three parameters of the MRI findings. The grade of van triculomegaly correlated well with the severity of cerebral palsy (CP) but not with the severity of mental impairment. The grade of reduction of periv entricular white matter correlated well with the severity of CP and mental impairment, and is the most reliable parameter for neurological prognosis. The degree of periventricular hyperintensity on T2-weighted images did not correlate well with severity of CP, but correlated to some degree with ment al impairment. There was a significantly lower degree of periventricular hy perintensity in children at less than 28 weeks of gestation than at 28 or m ore weeks of gestation, but no significant difference in other parameters. The periventricular hyperintensity should be evaluated in view of the gesta tional age.