Magnetic resonance imaging (MRI) findings of 70 children with periventricul
ar leukomalacia (PVL), examined between 1 year 2 months and 8 years of age
(mean: 2 years 4 months of age), were analysed. Neurological assessments we
re made between 1 year 3 months and 15 years (mean: 4 years 9 months). The
possible correlations between MRI findings and clinical profiles of PVL wer
e investigated using three parameters of the MRI findings. The grade of van
triculomegaly correlated well with the severity of cerebral palsy (CP) but
not with the severity of mental impairment. The grade of reduction of periv
entricular white matter correlated well with the severity of CP and mental
impairment, and is the most reliable parameter for neurological prognosis.
The degree of periventricular hyperintensity on T2-weighted images did not
correlate well with severity of CP, but correlated to some degree with ment
al impairment. There was a significantly lower degree of periventricular hy
perintensity in children at less than 28 weeks of gestation than at 28 or m
ore weeks of gestation, but no significant difference in other parameters.
The periventricular hyperintensity should be evaluated in view of the gesta