Growth factor independence and BCR/ABL transformation: promise and pitfalls of murine model systems and assays

Citation
S. Ghaffari et al., Growth factor independence and BCR/ABL transformation: promise and pitfalls of murine model systems and assays, LEUKEMIA, 13(8), 1999, pp. 1200-1206
Citations number
65
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
LEUKEMIA
ISSN journal
0887-6924 → ACNP
Volume
13
Issue
8
Year of publication
1999
Pages
1200 - 1206
Database
ISI
SICI code
0887-6924(199908)13:8<1200:GFIABT>2.0.ZU;2-8
Abstract
The expression of the BCR-ABL fusion oncoprotein in primitive hematopoietic cells results in chronic myeloid leukemia. Over the past decade studies of several in vitro and in vivo cell systems revealed multiple signal transdu ction pathways activated by BCR-ABL. However, the precise function of BCR-A BL in the pathogenesis of CML is still unclear. The goal of this review is to synthesize data on intracellular signaling in the context of the diverse murine assay systems employed. We emphasize the importance of in vivo assa ys and assays using primary cells in understanding the biology of CML and t he molecular mechanisms by which BCR-ABL exerts its effects.