Diet texture modifies outcome of a primary infection with Heligmosomoides polygyrus (Nematoda) in mice

Citation
Me. Scott et al., Diet texture modifies outcome of a primary infection with Heligmosomoides polygyrus (Nematoda) in mice, J PARASITOL, 85(4), 1999, pp. 761-765
Citations number
23
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Biology,Microbiology
Journal title
JOURNAL OF PARASITOLOGY
ISSN journal
0022-3395 → ACNP
Volume
85
Issue
4
Year of publication
1999
Pages
761 - 765
Database
ISI
SICI code
0022-3395(199908)85:4<761:DTMOOA>2.0.ZU;2-P
Abstract
TO determine if dietary texture altered the establishment, survival and rep roduction of Heligmosomoides polygyrus during a primary infection, commerci al mouse chow (Purina Chow(R)) was fed in either pelleted or powdered form to 2 groups of infected BALB/c mice, and a semipurified, biotin-fortified, egg-white-based diet was provided in powdered form to a third group of mice . Diet texture (powdered vs. pelleted) modified parasite establishment, as evidenced by higher worm recovery 6 days postinfection (PI) in both groups of mice fed powdered diets compared with the group fed the pelleted diet, b ut diet texture had no detectable effect on net or per capita egg productio n or on day 30 worm survival. However, almost twice as many worms were reco vered from mice fed the semipurified, powdered diet than those fed either t extural formulation of the commercial mouse chow on day 30 PI, indicating t hat a dietary component in the semipurified diet, such as the single fiber source cellulose, facilitated parasite survival, or that other ingredients in the commercial mouse chow, perhaps the more complex fiber components. re duced worm survival, or both. We conclude that dietary texture influences p arasite establishment and that specific fibers that change texture can indi vidually and independently modify H. polygyrus survival.