A beneficial effect on mood in partial epilepsy patients treated with gabapentin

Citation
Cl. Harden et al., A beneficial effect on mood in partial epilepsy patients treated with gabapentin, EPILEPSIA, 40(8), 1999, pp. 1129-1134
Citations number
27
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
EPILEPSIA
ISSN journal
0013-9580 → ACNP
Volume
40
Issue
8
Year of publication
1999
Pages
1129 - 1134
Database
ISI
SICI code
0013-9580(199908)40:8<1129:ABEOMI>2.0.ZU;2-D
Abstract
Purpose: Antiepileptic drugs (AEDs) are frequently used for their beneficia l psychoactive effects on affective disorders. We sought to demonstrate a p sychoactive effect of gabapentin (GBP) when used as add-on AED therapy. Methods: Forty adult patients with partial epilepsy were studied in a prosp ective, non-randomized fashion with interviewer-rated and self-rated scales of mood and anxiety: the Cornell Dysthymia Rating Scale (CDRS), Beck Depre ssion Inventory (BDI), and Hamilton Depression (Ham-D) and Anxiety (Ham-A) Scales. After completion of baseline mood and anxiety scales (time 1), 20 o f the 40 patients were prescribed add-on GBP (treated group). The remaining 20 patients served as a control group. Both groups were similar in age and sex distribution, Follow-up mood and anxiety scales were performed in all patients similar to 3 months later (time 2). The average GBP dose at time 2 was 1,615 mg/day. All patients were taking stable doses of one to four AED s at baseline and throughout the study. Seizure frequency was monitored thr oughout. Statistical significance was assessed by analysis of variance (ANO VA) by using a two-factor repeated-measures model. Results: The GBP-treated group had a significant decrease in CDRS score ove r time compared with the control group (p = 0.04). No significant differenc es between the control and the treated groups were found for any of the rem aining mood scales (BDI, p = 0.58; Ham-D, p = 0.59; Ham-A, p = 0.93). There was no significant difference or change in seizure frequency between group s. Conclusions: GBP treatment is associated with mood improvement as measured by the CDRS, This improvement was not accounted for by seizure improvement.