Effects of acute and chronic administration of methamphetamine or phencyclidine on plasma adrenocorticotropin, corticosterone and progesterone in rat

Citation
Y. Shirayama et al., Effects of acute and chronic administration of methamphetamine or phencyclidine on plasma adrenocorticotropin, corticosterone and progesterone in rat, ADDICT BIOL, 4(3), 1999, pp. 345-350
Citations number
30
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Neurosciences & Behavoir
Journal title
ADDICTION BIOLOGY
ISSN journal
1355-6215 → ACNP
Volume
4
Issue
3
Year of publication
1999
Pages
345 - 350
Database
ISI
SICI code
1355-6215(199907)4:3<345:EOAACA>2.0.ZU;2-M
Abstract
The effects of acute and chronic administration of methamphetamine (MAP) or phencyclidine (PCP) on the plasma adrenocorticotropin (ACTH), corticostero ne and progesterone in rats were examined. Acute administration of MAP (4.6 mg/kg i.p.) or PCP (10 mg/kg i.p.) increased significantly plasma ACTH, co rticosterone and progesterone. In contrast, no changes of ACTH, corticoster one, and progesterone were found with chronic administration of MAP (4.6 mg /kg i.p. once daily for II days) or PCP (10 mg/kg i.p. once daily for II da ys). These results suggest that acute, but not chronic, administration of M AP or PCP could modify hypothalamic-pituitary-adrenal (HPA) axis and hypoth alamic-pituitary-gonadotropin (HPG) axis endocrine responses in rats.