Direct enantiomeric separation of N-aminoethylamino acids: determination of the enantiomeric excess of chiral peptide nucleic acids (PNAs) by GC

Citation
R. Corradini et al., Direct enantiomeric separation of N-aminoethylamino acids: determination of the enantiomeric excess of chiral peptide nucleic acids (PNAs) by GC, TETRAHEDR-A, 10(11), 1999, pp. 2063-2066
Citations number
15
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
TETRAHEDRON-ASYMMETRY
ISSN journal
0957-4166 → ACNP
Volume
10
Issue
11
Year of publication
1999
Pages
2063 - 2066
Database
ISI
SICI code
0957-4166(19990604)10:11<2063:DESONA>2.0.ZU;2-7
Abstract
Direct chiral separation of N-aminoethylamino acids has been performed for the first time by gas chromatographic (GC) analysis with a Chirasil-Val col umn, after derivatisation with trifluoroacetic anhydride in dichloromethane , which led to the corresponding piperazin-2-one derivatives, as identified by NMR and GC/MS analysis. The method was used for the analysis of the ena ntiomeric excess of chiral peptide nucleic acid (PNA) monomers and oligomer s after hydrolysis with 6N HCl. (C) 1999 Elsevier Science Ltd. All rights r eserved.