Applications of amorphous track models in radiation biology

Citation
Fa. Cucinotta et al., Applications of amorphous track models in radiation biology, RADIAT ENV, 38(2), 1999, pp. 81-92
Citations number
77
Language
INGLESE
art.tipo
Review
Categorie Soggetti
Multidisciplinary
Journal title
RADIATION AND ENVIRONMENTAL BIOPHYSICS
ISSN journal
0301-634X → ACNP
Volume
38
Issue
2
Year of publication
1999
Pages
81 - 92
Database
ISI
SICI code
0301-634X(199907)38:2<81:AOATMI>2.0.ZU;2-H
Abstract
The average or amorphous track model uses the response of a system to gamma -rays and the radial distribution of dose about an ion's path to describe s urvival and other cellular endpoints from proton, heavy ion, and neutron ir radiation. This model has been used for over 30 years to successfully fit m any radiobiology data sets. We review several extensions of this approach t hat address objections to the original model, and consider applications of interest in radiobiology and space radiation risk assessment. In the light of present views of important cellular targets, the role of target size as manifested through the relative contributions from ion-kill (intra-track) a nd gamma-kill tinter-track) remains a critical question in understanding th e success of the amorphous track model. Several variations of the amorphous model are discussed, including ones that consider the radial distribution of event-sizes rather than average electron dose, damage clusters rather th an multiple targets, and a role for repair or damage processing.