Oligonucleotides with 2,6-diaiminopurine base replacing for adenine: Synthesis and properties

Citation
V. Boudou et al., Oligonucleotides with 2,6-diaiminopurine base replacing for adenine: Synthesis and properties, NUCLEOS NUC, 18(6-7), 1999, pp. 1429-1431
Citations number
5
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Biochemistry & Biophysics
Journal title
NUCLEOSIDES & NUCLEOTIDES
ISSN journal
0732-8311 → ACNP
Volume
18
Issue
6-7
Year of publication
1999
Pages
1429 - 1431
Database
ISI
SICI code
0732-8311(1999)18:6-7<1429:OW2BRF>2.0.ZU;2-Y
Abstract
Synthesis of three nucleoside building blocks with a benzoyl protected diam inopurine (DAP) base and their incorporation at different positions of DNA, RNA and hexitol oligomers (HNA) have been accomplished. DNA hairpins with a DAP substituted for one (or more) adenine in the loop structure were not found to be more stable. But the stability of RNA-hexitol as well as hexito l-hexitol duplexes improved when the adenine base was replaced with DAP.