Balloon pump-induced pulsatile perfusion during cardiopulmonary bypass does not improve brain oxygenation

Citation
F. Kawahara et al., Balloon pump-induced pulsatile perfusion during cardiopulmonary bypass does not improve brain oxygenation, J THOR SURG, 118(2), 1999, pp. 361-366
Citations number
30
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cardiovascular & Respiratory Systems","Cardiovascular & Hematology Research
Journal title
JOURNAL OF THORACIC AND CARDIOVASCULAR SURGERY
ISSN journal
0022-5223 → ACNP
Volume
118
Issue
2
Year of publication
1999
Pages
361 - 366
Database
ISI
SICI code
0022-5223(199908)118:2<361:BPPPDC>2.0.ZU;2-6
Abstract
Background: Whether pulsatile flow offers substantial advantages for brain protection during cardiopulmonary bypass is controversial. The purpose of t his study is to determine whether differences exist between pulsatile and n onpulsatile bypass concerning the effects on internal jugular venous satura tion and on the state of regional cerebral oxygenation during normothermia, Methods: Twenty-two patients undergoing elective coronary artery bypass gr afting were randomly divided into 2 groups: group 1 (n = 11) received nonpu lsatile perfusion during cardiopulmonary bypass and group 2 (n = 11) receiv ed pulsatile perfusion during bypass. We used an intra-aortic balloon pump; to generate pulsatility, A spectrophotometric probe (INVOS 3100R, Somanetic s, Troy, Mich) was used to assess the state of regional cerebral oxygenatio n, A 4F fiberoptic oximetry oxygen saturation catheter was inserted into th e right jugular bulb to monitor jugular venous oxygen saturation, Hemodynam ic variables, arterial and jugular venous blood gases, and regional cerebra l oxygenation were measured at 7 times points. Results: In both groups, jug ular venous oxygen saturation decreased at the early stage of the cardiopul monary bypass (P = .03). Five patients in group 1 and 6 in group 2 had a ju gular venous oxygen saturation of less than 50%, In both groups, the region al cerebral oxygenation value decreased during cardiopulmonary bypass (P = .04). Conclusions: The present results showed that pulsatility generated th rough the use of intra-aortic balloon pumping did not produce any beneficia l effects on jugular venous oxygen saturation and regional cerebral oxygena tion at normothermia.