Hyperthermic isolated regional perfusion for the treatment of osteosarcomain the lower extremity

Citation
H. Nakano et al., Hyperthermic isolated regional perfusion for the treatment of osteosarcomain the lower extremity, AM J SURG, 178(1), 1999, pp. 27-32
Citations number
18
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Surgery,"Medical Research Diagnosis & Treatment
Journal title
AMERICAN JOURNAL OF SURGERY
ISSN journal
0002-9610 → ACNP
Volume
178
Issue
1
Year of publication
1999
Pages
27 - 32
Database
ISI
SICI code
0002-9610(199907)178:1<27:HIRPFT>2.0.ZU;2-G
Abstract
BACKGROUND: In order to reduce the systemic toxity of cisplatin and to incr ease the effect on the local tumor, facilitating limb-preserving procedures , we have been using hyperthermic isolated regional perfusion (HIRP) for th e treatment of osteosarcoma in addition to preoperative chemotherapy. MATERIALS AND METHODS: Twenty patients with an osteosarcoma in a lower extr emity were treated with both preoperative chemotherapy and HIRP. RESULTS: The chemotherapeutic effects of preoperative chemotherapy with HIR P was grade III in 6, and grade IV (no viable cell areas observed) in 7. Th e surgical margins could be reduced in these 13 cases of good responders sh owing over 90% necrosis (grade III or grade IV), which mainly involved post necrotic fibrosis and osteosclerosis. CONCLUSION: HIRP can help to control the tumor locally. A more conservative operation was then possible in cases of good responders to preoperative ch emotherapy with HIRP. Am J Surg. 1999;178:27-32. (C) 1999 by Excerpta Medic a, Inc.