Integrin-linked kinase (ILK): a regulator of integrin and growth-factor signalling

Citation
S. Dedhar et al., Integrin-linked kinase (ILK): a regulator of integrin and growth-factor signalling, TR CELL BIO, 9(8), 1999, pp. 319-323
Citations number
38
Language
INGLESE
art.tipo
Article
Categorie Soggetti
Cell & Developmental Biology
Journal title
TRENDS IN CELL BIOLOGY
ISSN journal
0962-8924 → ACNP
Volume
9
Issue
8
Year of publication
1999
Pages
319 - 323
Database
ISI
SICI code
0962-8924(199908)9:8<319:IK(ARO>2.0.ZU;2-S
Abstract
Interaction of cells with the extracellular matrix (ECM) results in the reg ulation of cell growth, differentiation and migration by coordinated signal transduction through integrins and growth-factor receptors. Integrins achi eve signalling by interacting with intracellular effecters that couple inte grins and growth-factor receptors to downstream components. One well-studie d effector is focal-adhesion kinase (FAK) but recently another protein kina se, integrin-linked kinase (ILK) has been identified as a receptor-proximal effector of integrin and growth-factor signalling. ILK appears to interact with and be influenced by a number of different signalling pathways, and t his provides new routes for integrin-mediated signalling. This article disc usses ILK structure and function and recent genetic and biochemical evidenc e about the role of ILK in signal transduction.